During year 3, clinical studies within the TransBioLine project are progressing in the enrolment of patients to move forward in the identification of novel biomarkers that reliably indicate specific organ injury during drug development.
Status of clinical studies per centre and organ work package as of 16 March 2022
| Drug induced KIDNEY injury (WP1) | Pre-eclampsia | anti-VEGF | ||
|---|---|---|---|---|
| University of Zurich (CH) | enrolling | enrolling | ||
| University of Munich (GE) | enrolling | enrolling | ||
| University of Malaga/ Servicio Andaluz de Salud (ES) | enrolling | - | ||
| University of Bern (GE) | approved | - |
| Drug induced LIVER injury (WP2) | DILI | ALF | NAFLD | Methotraxate |
|---|---|---|---|---|
| University of Nottingham (UK) | enrolling | enrolling | enrolling | enrolling |
| University of Zurich (CH) | enrolling | - | - | - |
| University of Munich (GE) | enrolling | - | - | - |
| University of Malaga/ Servicio Andaluz de Salud (ES) | enrolling | - | - | - |
| Landspitali University Hospital (IS) | enrolling | - | - | - |
| Assistance Publique – Hopitaux de Paris (FR) | approved | - | - | - |
| University of Bern (GE) | enrolling | - | - | - |
| Drug induced PANCREAS injury (WP3) | MAP-1 | |||
|---|---|---|---|---|
| University of Liverpool (UK) | approved | |||
| University of Munich (GE) | not yet submitted | |||
| University of Malaga/ Servicio Andaluz de Salud (ES) | approved |
| Drug induced VASCULAR injury (WP4) | Vasculitides | Angioplasty |
|---|---|---|
| University of Zurich (CH) | enrolling | enrolling |
| University of Malaga/ Servicio Andaluz de Salud (ES) | enrolling | - |
| Drug induced CNS injury (WP5) | TBI | MS | ChemoBrain | NHV |
|---|---|---|---|---|
| Charité – Berlin University Hospital (GE) | - | completed | completed | completed |
| Pfizer | completed | - | - | enrolling |
| Liquid biopsies (WP6) | NHV | |||
|---|---|---|---|---|
| Janssen | enrolling |
enrolling: trial is running, patient recruitment is underway
approved: ethical approval has been received, patients not yet being recruited
submitted: study awaiting ethical approval, documents submitted to local ethical committee
not yet submitted: documents will be submitted for ethical approval shortly
completed: patients no longer being recruited
-: not planned/not applicable